Acciliv Injection

Acciliv Injection

USD 1.5 / Pieces
Country of Origin India (India)
MOQ 5000 Pieces
Price USD 1.5 / Pieces
Category Health & Medical Personal Care

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ACCILIV INJECTION

Hepatic encephalopathy (HE) is a potentially reversible functional disorder of the brain with neurological and psychiatric symptoms. HE occurs in up to 70% of patients with cirrhosis at some time during the course of disease. The chief neurotoxin implicated in the development of HE is ammonia. An important aim of treatment of HE is the reduction of the ammonia in the body by lowering the amount of ammonia produced and increasing its detoxification. Enteric production of ammonia can be decreased by non-absorbable disaccharides such as lactulose and antibiotics such as rifaximin.

L-ornithine- L-aspartate (LOLA), the salt of the natural amino acids ornithine and aspartate acts through the mechanism of substrate activation to detoxify ammonia. In clinical trials, LOLA has shown a statistically significant effect with respect to reduction in HE grade, reduction of blood ammonia concentration and positive effects on psychomotor function in patients of cirrhosis with minimal HE and overt chronic Grade I HE, as compared to placebo.

However, there is lack of data on the efficacy of LOLA in patients with overt acute hepatic encephalopathy which is one of the major causes of hospital admissions and resource utilization in decompensated cirrhotics. Each admission for HE causes a major financial loss to the family and financial burden on the society. Any drug which decreases the hospital stay by rapidly improving HE, will clearly lead to decreased hospital costs to the individual and the society as a whole.

Hence, such a trial is a national priority. The investigators hypothesize that LOLA, if added to the standard treatment of overt acute HE (i.e lactulose), may lead to a faster recovery and decrease in hospital stay of these patients. In this prospective, randomized, placebo controlled trial, the investigators aim to evaluate the efficacy of intravenous L-ornithine, L-aspartate in reversal of overt acute hepatic encephalopathy in patients with liver cirrhosis.

Shunt placement, prophylactic use of LOLA infusion is safe and effective in reducing post-prandial increases in venous ammonia concentration .

Country of Origin: India (India)
Sample Policy:
Payment Terms: 100% ADVANCE
Packaging Info: 1 x 10 ML PACKED IN OUTER BOX

Product Specification

Brand Name : ACCILIV

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Supplier Info

Company Name :

India Accilex Nutri Crop

Business Type :
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  • Manufacturer
Supplier Phone: : +9194244xxxxx
We take much pride in introducing you to one of the pioneers in the pharmaceuticals Industry, “Sudhir Life Sciences Pvt. Ltd. which has been in the Pharmaceuticals business for more than a 65 years and still counting. Sudhir Life Sciences Pvt Ltd. (AN ISO 9001: 2015 Certified Co), a proud... View Profile

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Accilex Nutri Crop

Madhya Pradesh, India

Year Established: 1963

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